Women are at higher risk of Alzheimer's and other neurological diseases after menopause, and yet research connecting female brain health to sex hormone fluctuations is limited. We seek to investigate this connection by developing tools that quantify 3D shape changes that occur in the brain during sex hormone fluctuations. Geodesic regression on the space of 3D discrete surfaces offers a principled way to characterize the evolution of a brain's shape. However, in its current form, this approach is too computationally expensive for practical use. In this paper, we propose approximation schemes that accelerate geodesic regression on shape spaces of 3D discrete surfaces. We also provide rules of thumb for when each approximation can be used. We test our approach on synthetic data to quantify the speed-accuracy trade-off of these approximations and show that practitioners can expect very significant speed-up while only sacrificing little accuracy. Finally, we apply the method to real brain shape data and produce the first characterization of how the female hippocampus changes shape during the menstrual cycle as a function of progesterone: a characterization made (practically) possible by our approximation schemes. Our work paves the way for comprehensive, practical shape analyses in the fields of bio-medicine and computer vision. Our implementation is publicly available on GitHub: https://github.com/bioshape-lab/my28brains.

Shape displays are a class of haptic devices that enable whole-hand haptic exploration of 3D surfaces. However, their scalability is limited by the mechanical complexity and high cost of traditional actuator arrays. In this paper, we propose using electroadhesive auxetic skins as a strain-limiting layer to create programmable shape change in a continuous ("formable crust") shape display. Auxetic skins are manufactured as flexible printed circuit boards with dielectric-laminated electrodes on each auxetic unit cell (AUC), using monolithic fabrication to lower cost and assembly time. By layering multiple sheets and applying a voltage between electrodes on subsequent layers, electroadhesion locks individual AUCs, achieving a maximum in-plane stiffness variation of 7.6x with a power consumption of 50 uW/AUC. We first characterize an individual AUC and compare results to a kinematic model. We then validate the ability of a 5x5 AUC array to actively modify its own axial and transverse stiffness. Finally, we demonstrate this array in a continuous shape display as a strain-limiting skin to programmatically modulate the shape output of an inflatable LDPE pouch. Integrating electroadhesion with auxetics enables new capabilities for scalable, low-profile, and low-power control of flexible robotic systems.

Nature provides several examples of organisms that utilize shape change as a means of operating in challenging, dynamic environments. For example, the spider Araneus Rechenbergi [1, 2] and the caterpillar of the Mother-of-Pearl Moth (Pleurotya ruralis) [3] transition from walking gaits to rolling in an attempt to escape predation. Across larger time scales, caterpillar-tobutterfly metamorphosis enables land to air transitions, while mobile to sessile metamorphosis, as observed in sea squirts, is accompanied by radical morphological change. Inspired by such change, engineers have created caterpillar-like rolling [4], modular [5, 6, 7], tensegrity [8, 9], plant-like growing [10], and origami [11, 12] robots that are capable of some degree of shape change. However, progress toward robots which dynamically adapt their resting shape to attain different modes of locomotion is still limited. Further, design of such robots and their controllers is still a manually intensive process. Despite the growing recognition of the importance of morphology and embodiment on enabling intelligent behavior in robots [13], most previous studies have approached the challenge of operating in multiple environments primarily through the design of appropriate control strategies.

A robot's mechanical parts routinely wear out from normal functioning and can be lost to injury. For autonomous robots operating in isolated or hostile environments, repair from a human operator is often not possible. Thus, much work has sought to automate damage recovery in robots. However, every case reported in the literature to date has accepted the damaged mechanical structure as fixed, and focused on learning new ways to control it. Here we show for the first time a robot that automatically recovers from unexpected damage by deforming its resting mechanical structure without changing its control policy. We found that, especially in the case of "deep insult", such as removal of all four of the robot's legs, the damaged machine evolves shape changes that not only recover the original level of function (locomotion) as before, but can in fact surpass the original level of performance (speed). This suggests that shape change, instead of control readaptation, may be a better method to recover function after damage in some cases.

Shape-changing hydrogels that can bend, twist, or actuate in response to external stimuli are critical to soft robots, programmable matter, and smart medicine. Shape change in hydrogels has been induced by global cues, including temperature, light, or pH. Here we demonstrate that specific DNA molecules can induce 100-fold volumetric hydrogel expansion by successive extension of cross-links. We photopattern up to centimeter-sized gels containing multiple domains that undergo different shape changes in response to different DNA sequences. Experiments and simulations suggest a simple design rule for controlled shape change.